Aula introdutória sobre Farmacocinética e entrega de cronogramas com divisão dos artigos científicos

1) Site-Specific Chemical Modification of Human Serum Albumin with Polyethylene Glycol Prolongs Half-life and Improves Intravascular Retention in Mice. Biol. Pharm. Bull. 35(3) 280?288 (2012) 2) The Effect of Gastric Bypass on the Pharmacokinetics of Serotonin Reuptake Inhibitors. (Am J Psychiatry 2012; 169:256?263) 3) Determination of gemifloxacin on dried blood spots by hydrophilic interaction liquid chromatography with fluorescence detector: application to pharmacokinetics in rats. Biomed. Chromatogr. 2012 4) Alcohol pharmacokinetics and risk-taking behaviour following exercise-induced dehydration. Pharmacology, Biochemistry and Behavior 101(4)(2012) 609?616

1) Disposition of Human Recombinant Lubricin in Naive Rats and in a Rat Model of Post-traumatic Arthritis After Intra-articular or Intravenous Administration. The AAPS Journal, Vol. 14, No. 1, March 2012 (# 2011) 2) Pharmacokinetics of Valerenic Acid in Rats after Intravenous and Oral Administrations. Planta Médica online january, 2012 3) Heat Exposure of Cannabis sativa Extracts Affects the Pharmacokinetic and Metabolic Profile in Healthy Male Subjects. Planta Medica online february, 2012 4) Inhibitory Effect of Ketoconazole on the Pharmacokinetics of a Multireceptor Tyrosine Kinase Inhibitor BMS-690514 in Healthy Participants: Assessing the Mechanism of the Interaction With Physiologically-Based Pharmacokinetic Simulations. J Clin Pharmacol published online 19 March 2012

1) Effect of neuroleptics on cytochrome P450 2C11 (CYP2C11) in rat liver. Pharmacological Reports, 2011, 63:1491-1499 2) CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers. Eur J Clin Pharmacol, online, March, 2012 3) Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial. BMC Clinical Pharmacology 2012, 12:8 4) Drug?Drug Interaction Potential of Marketed Oncology Drugs: In Vitro Assessment of Time-Dependent Cytochrome P450 Inhibition, Reactive Metabolite Formation and Drug?Drug Interaction Prediction. Pharm Res, online, March, 2012.

- Teoria de receptores - Interação Droga-receptor - modelo de acoplamento droga-receptor - Parâmetros farmacológicos - Noções de sinalização celular

-Receptor theory in pharmacology- Terry Kenakin. Assay Development Compound ProfilingTRENDS in Pharmacological Sciences Vol.25 No.4 April 2004.

-A holistic view of GPCR signaling. Terry Kenakin, Nature Biotechnology, 2010.

-Efficacy as a Vector: the Relative Prevalence and Paucity  of Inverse Agonism. Terry Kenakin, 2003

-Receptor theory in Pharmacology- Terry Kenakin, 2004

 

-Signaling and regulation of G protein-coupled receptors in airway smooth muscle - Charlotte K Billington, 2002.

-Pharmacological characterization of muscarinic receptor subtypes mediating vasoconstriction of human umbilical vein - Virginia Andrea Pujol Lereis, 2006.

-Coupling mode of receptors and G proteins. Naunyn-Schmied Arch Pharmacol. 2008.

 

- Targeting by Myosin Phosphatase-RhoA Interacting Protein Mediates RhoA/ROCK Regulation of Myosin Phosphatase,- Nadeene Riddick, 2008.

 

- Opioid Agonists Have Different Efficacy Profiles for G Protein  Activation, Rapid Desensitization, and Endocytosis of  Mu-opioid Receptors - Stephanie L. Borgland, 2003.